Nephrotic Syndrome Accompanied with Kidney Function Decline

Nephrotic Syndrome is featured by proteinuria, hypoproteinemia, serious edema and hyperlipemia. In general, Nephrotic Syndrome is not accompanied with kidney function decline, and these external symptoms can be controlled effectively by corticosteroids or similar like medicines. However, once there is substantial damage like in case of FSGS, only corticosteroid medicine is not enough.
Though the pathological mechanism of Nephritic Syndrome is not quiet clear, but it is kind of related to immune system. In treating Nephritic Syndrome, immunosuppressant or similar like medicines are adopted to suppress immune system. Symptoms like proteinuria can be controlled effectively, but patients are prone to relapse of Nephrotic Syndrome. Most patients tend to judge whether Nephrotic Syndrome is treated well or not by whether proteinuria become negative or not. However, most patients ignore the actual damages in kidneys.
Nephrotic Syndrome accompanied with kidney function decline is featured by a bad prognosis.
Nephrotic Syndrome can also be accompanied with serious kidney damage, such as IgA deposition on kidneys or in cases of FSGS. All these pathological changes indicate substantial damage or necrosis of functional kidney cells. Kidney differs from other organs in that once t there is cellular necrosis, kidney can not automatically regenerate new functional cells to replace there died ones, so any necrosis or sclerosis of kidney cells is an absolute loss of overall kidney function.
Proteinuria aggravates the pathological changes of kidney cells, and damage of kidney cells in turn permits more protein leakage into urine.
In such cases, corticosteroids or similar like medicine is not enough. And blocking further kidney function decline and promoting overall kidney function become even more important.
In short, once Nephrotic Syndrome is accompanied with kidney function decline, the treatment should be focused on promoting overall kidney function, as well as treating external symptoms, if you have any questions, You can send me.