How to Prevent the Complications of Membranous Nephropathy

Membranous nephropathy is a common chronic kidney disease among middle-aged and senior men. Most of the patients would present mass proteinuria as a result of pathological changes in glomeruli, as well as hypoproteinemia, severe edema and hyperlipemia, in which case the following complications are very likely to happen:
1. infection
Because of massive loss of immunoglobin in the urine and long-term intake of immunosuppressants, patients with membranous nephropathy would have remarkably low body resistance and are very likely to develop infections, including upper respiratory infection(cold), pulmonary infection(like cough, phlegm and fever), enteral infection(nausea, vomit, diahhrea and fever). At the same time, patients with overt edema tend to have their skin impaired, causing partial infections.
With this in mind, patients should prevent cold, avoid fatigue and insanitary foods. If patients have symptoms such as fever, cough and phlegm, they should go to hospital to do blood test and chest x-ray. Then they should receive relevant treatment based on their conditions.
2. thrombosis and complications of thrombosis:
Compared with other forms of kidney disease, patients with membranous nephropathy are more prone to thrombosis and its complications. This is because 1.serious hypoproteinemia would lower the POP (plasma oncotic pressure) 2.liver composes lipoprotein and other substances that boost cruor.3.excessive diuresis in some patients.
If the patients have high concentration state in their blood, they should be treated with relevant medications. At the same time, patients should exercise moderately, like jogging.
3. acute renal insufficiency
Patients with membranous nephropathy would experience declining blood perfusion in kidneys as their severe edema, hypoproteinemia and insufficient blood volume. In some cases, because of excessive diuresis and improper use of antihypertensive, the GFR would lower further, resulting in renal acute insufficiency.
So, patients with membranous nephropathy should check their renal function on a regular basis.
4. metabolic disorder of protein and fat
Long-standing hypoalbuminemia would cause malnutrition, which would affect the growth of the children. Less haemocyanin would increase the concentration of the drugs in plasma, boosting the toxicity of the medications.
Massive proteinuria could cause hyperlipemia, which not only increases the incidence of the cardio-vascular events, but also promotes the proliferation of the mesangial cells and the hardening of the glomeruli.
So, patients with membranous nephropathy should limit the intake of protein and lipid on the premise that they have enough nutrition supply.
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